The concept for Herron High School began in 2003 under the leadership of the Harrison Center for the Arts, which gathered neighborhood residents, non-profits, and businesses to create a unique school designed to grow Indianapolis' creative class and to serve the downtown community. Exploration funds for this endeavor were provided through the University of Indianapolis' Center of Excellence in Leadership of Learning (CELL).

Herron High School was granted its charter status by Indianapolis Mayor Bart Peterson. It opened its doors to 100 9th grade students in the fall of 2006.